Study of isoforms of nicotinamide adenine dinucleotide phosphate oxidase of the heart in a model of rats fed on several vegetable oils

Palm oil has long been incriminated in obesity, and this obesity would be responsible for the development of cardiac fibrosis, several authors have evoked role free radicals pathophysiological mechanism fibrotic response linked to obesity; aim study was therefore evaluate profile NOX2 fibrosis rats subjected a diet rich fat vegetable oils, case palm oil. A total forty young male Wistar were diets (soybean, red branched oil, olive lard). After twelve weeks experimentation, sacrificed after anaesthesia, parameters oxidative stress, inflammation level interstitial heart assessed. Our showed that consumption did not lead overexpression stress inflammatory RNA markers. The expression myocardial nicotine adenine dinucleotide phosphate oxidase change consuming compared control diet. However, olein, lard resulted significant activity. This seems show because its richness antioxidants, less deleterious heart.   Key words: Oxidative stress-inflammation-palm oil-cardiac fibrosis.